Programme
Wednesday, August 29th
2.00-3.30 Registration 3.30 Conference Opening
Session I: New views on protein allostery (Chairpersons: A. Bellelli, C. Viappiani) 3.45-4.15 W. A. Eaton, NIH, USA. Remaining issues for hemoglobin allostery 4.15-4.45 T. Spiro, Princeton University, USA. Intermediate steps in the allosteric pathway of Hb from resonance Raman spectroscopy 4.45-5.15 J. Tame, Yokohama City University, Japan. Beyond structure 5.15-5.35 T. Yonetani, University of Pennsylvania, USA. Gate-Keeper Mechanism of Modulation of O2-Affinity in Hb 5.35-5.55 K. Olsen, Loyola University, Chicago, USA. Molecular Dynamics Simulations of Allosteric Effects and Oxygen Binding in Human Hemoglobin
6.30 Welcome buffet
Thursday, August 30th
Session II: Sensing and signalling proteins (Chairpersons: R. Poole, S. Bettati)
9.00-9.30 M. H. Vos, Ecole Polytechnique, France. Ligand dynamics in the heme domain of sensor proteins 9.30-10.00 R. Poole, University of Sheffield, UK. Oxygen sensing and utilisation in Escherichia coli in environments with dynamic oxygen concentrations 10.00-10.30 B. Pioselli, Chiesi Pharmaceuticals, Italy. Mobilizing ions down to the molecular basis of lung surfactant
10.30-11.00 Coffee break
11.00-11.20 F. Licausi, Scuola Superiore Sant'Anna, Italy. Oxygen sensing and signaling in plants: a story about oxygen dependent protein sequestration and degradation 11.20-11.40 L. Tilleman, University of Antwerp, Belgium. C. elegans GLB-26, a redox signaling protein 11.40-11.50 B. Zeis, Muenster University, Germany. Hypoxia-inducible hemoglobins of Daphnia pulex: molecular mechanisms and physiological consequences of differential expression 11.50-12.00 M. Knipp, Max Planck Institute for Chemical Energy Conversion, Germany. Association and Dissociation Kinetics of CO to Nitrophorin 4 and 7 12.00-12.10 A. Oliveira, Barcelona University, Spain. Structural and dynamical analysis of Nitrophorin 7 12.10-12.20 K. Nienhaus, Karlsruhe Institute of Technology, Germany. CO Recombination in IDO and TDO – A Comparison 12.20-12.30 J. Lecomte, Johns Hopkins University, USA. Influence of heme post-translational modification and distal ligation on the backbone dynamics of a monomeric hemoglobin 12.30-12.40 M. Dellarole, Johns Hopkins University, USA. The inner life of a monomeric hemoglobin: Detecting tunnels and cavities with high-pressure NMR and heteronuclear relaxation methods
1 pm Lunch
2.00-3.00 Poster session
Session III: Cytoglobin and Neuroglobin (chairpersons: T. Burmester, D. Estrin) 3.00-3.20 S. Dewilde, Antwerp University, Belgium. Functional analyses of neuroglobin based on transgenic experiments and other data 3.20-3.40 C. Lechauve, Universités Paris VI et XI, France. The involvement of neuroglobin in mitochondrial integrity 3.40-4.00 K. Wakasugi, University of Tokyo, Japan. Searches for physiological function of neuroglobin 4.00-4.20 X. Bailly, Station Biologique de Roscoff, CNRS-UPMC, France. Pivotal evolutionary functions of neuroglobins in metazoans : from protoneural cells/system emergence to the origin of hemoglobins 4.20-4.30 D. Greenberg, Buck Institute for Research on Aging, USA. Neuroglobin signaling in neuronal cells. 4.30-4.40 A. Nadra, Universidad de Buenos Aires, Argentina. Chimeric globins designed by morphing myoglobin and neuroglobin: Role of the CD segment on heme
4.40-5.10 Coffee break
5.10-5.30 B. J. Reeder, University of Essex, England. Cytoglobin interaction with lipids: Changes in protein structure (and function?) 5.30-5.50 P. Chiarugi, University of Florence, Italy. Oxygen, tumor and cytoglobin 5.50-6.00 S. Vermeylen, University of Antwerp, Belgium. Study of the role of cytoglobin in hypoxia and cancer: a molecular and epigenetic approach. 6.00-6.10 A. Bicker, Johannes Gutenberg University Mainz, Germany. Myoglobin in cancer cells – a function in tumor suppression?
6.30 Guided tour of Parma leaving from the 'Casa della Musica'
Friday, August 31st
Session IV: Hemoglobin and Myoglobin, old and novel friends (chairpersons: J. Olson, M. Bolognesi) 9.00-9.30 J. Olson, Rice University, USA. A sliding rule for ligand affinity and gates versus tunnels for ligand uptake and release 9.30-10.00 G. Richter-Addo, University of Oklahoma, USA. The structural biology of heme-NOx in Mb and Hb 10.00-10.30 S. Helbo, University of Aarhus, Denmark. Allosteric effects and enzymatic functions of fish myoglobins in protection against hypoxia 10.30-11.00 M. Marti, University of Buenos Aires, Argentina. The histidine gate in Mb revisited 11.00-11.15 M. A. Scorciapino, University of Cagliari, Italy. Human myoglobin: two naturally occurring isoforms, that differ at single residue, remarkably show different dynamics
11.15-11.45 Coffee break
11.45-12.15 V. Guallar, Barcelona Supercomputing Center, Spain. Ligand Trajectories in Hb 12.15-12.30 A. Vergara, University of Naples, Italy. A combined Raman microspectroscopic / crystallographic approach to photolytic and oxidative denitrosylation in hemoglobins 12.30-12.45 F. E. Lui, Massachusetts General Hospital and Harvard Medical School, USA. A Novel High-Throughput Assay of Hemoglobin Oxygen Affinity: Screening Small Molecules 12.45-1.00 M. Bolognesi, University of Milan, Italy. Summary and Review of Posters
1.00 pm Lunch
2.00-3.00 Poster session
Session V: Evolution of oxygen binding proteins (chairpersons: L. Moens, T. Hankeln) 3.00-3.30 T. Hankeln, Johannes Gutenberg University of Mainz, Germany. Arthropod Hemoglobins 3.30-3.50 S. Vinogradov. Wayne University, USA. State of the Globins 3.50-4.10 D. Hoogewijs, University of Zurich, Switzerland. Androglobin: a novel chimeric globin of ancient evolutionary origin in metazoans 4.10-4.30 F. Hoffmann, Mississippi State University, USA. The evolutionary framework of deuterostome and deep metazoan globins
4.30-5.00 Coffee break
5.00-5.20 T. Burmester, University of Hamburg, Germany. The evolution and function of vertebrate globins 5.20-5.40 J. Markl, Johannes Gutenberg University, Germany. Evolution of hemocyanin structures 5.40-5.50 J. Projecto-Garcia, University of Nebraska Lincoln, USA. Parallel evolution of hemoglobin function in Andean hummingbirds 5.50- 6.00 D. Giordano, Institute of Protein Biochemistry-CNR. Excess oxygen in the polar marine environment: the role of the 2/2 hemoglobin in the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125 6.00-6.10 R. E. Weber, University of Aharus, Denmark. Allosteric Modulation of Oxygen Affinity in Dwarf Caiman Hemoglobin that Lacks Conventional Proton and Anion Binding Sites
6.30-7.00 Discussion on the XVIII O2BiP meeting
7.00 Social Dinner
Saturday, September 1st
Session VI: Globins and hemocyanins: function and physiology (chairpersons: A. Fago, M. Hargrove, C. Verde) 9.00-9.30 J. F. Storz, University of Nebraska, USA. Nonadditive interaction effects between hemoglobin mutations: evolutionary implications 9.30-10.00 R. Sturms, Iowa University, USA). Anaerobic chemistry of plant hemoglobins; potential roles in hypoxic respiration and nitrogen utilization 10.00-10.20 J. Luque, Barcelona University, Spain. Computational analysis of the structural plasticity of internal cavities in globins 10.20-10.40 S. Gustincich, SISSA, Italy. Hemoglobin in dopaminergic neurons of the brain and neurodegenerative diseases 10.40-11.00 P. Ascenzi, University of Roma Tre, Italy. Estrogen-induced neuroglobin-cytochrome c interaction into mitochondria: protective effects against oxidative stress in neuronal cells
11.00-11.30 Coffee break
11.30-11.40 S. Abbruzzetti, University of Parma, Italy. Ligation tunes protein reactivity in an ancient haemoglobin. Kinetic evidence for an allosteric mechanism in Methanosarcina acetivorans protoglobin. 11.40-11.50 S. Kundu, University of Delhi South Campus, India. Striking Aspects of Stability of a Cyanobacterial Globin 11.50-12.00 G. Smulevich, University of Florence, Italy. Unique H-bonding interactions in the distal cavity of Thermobifida fusca hemoglobin: resonance Raman spectroscopy and molecular dynamics simulations. 12.00-12.10 K.L. Dikshit, CSIR Institute of Microbial Technology, India. Cellular localization and post-translational modification of truncated haemoglobin, HbN, in Mycobacterium tuberculosis 12.10-12.20 M. Coletta, University of Rome Tor Vergata, Italy. Isoniazid inhibits the heme-based reactivity of Mycobacterium tuberculosis truncated hemoglobin N 12.20-12.30 N. Hellmann, University of Mainz, Germany. Differential regulation of hexameric and dodecameric hemocyanin of Astacus leptodactylus. 12.30-1.00 J. Wittenberg, A. Einstein College of Medicine, USA. Cytoplasmic hemoglobins carry out two kinds of function
1.00 Conference Conclusions
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