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14:00 - 14:50     POSTER SESSION

14:50 – 15:00     CONGRESS OPENING

15:00 – 16:30     Chromatin and nuclear proteins (Chairperson: Simone Ottonello)

15:00 - 15:45        The epigenome and the transcriptional control of innate immunity and inflammation, Gioacchino Natoli, Department of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus, Milan, Italy

15:45 - 16:00        The histone demethylases LSD1 and LSD2: non-identical twins in repressor chromatin complexes, Claudia Binda, University of Pavia, Italy

16:00 - 16:15        The telomere-binding protein Tbf1 demarcates snoRNA gene promoters in Saccharomyces cerevisiae, Giorgio Dieci, University of Parma, Italy

16:15 - 16:30        Characterization of BldR2 from the archaeon Sulfolobus solfataricus: a new transcriptional regulator of the MarR family, Gabriella Fiorentino, University of Naples "Federico II", Italy
16:30 - 17:00     Coffee break

17:00 – 18:30     Genomics and protein function discovery (Chairperson: Anna Tramontano)

17:00 - 17:45        The universe of protein function, Alfonso Valencia, Structural Biology and Bio-computing Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

17:45 - 18:00        Structural and functional characterization of the Cul3 adaptor RENKCTD11, Sonia Di Gaetano, CNR Naples, Italy

18:00 – 18:15        A new mechanism of glyphosate tolerance by means of protein engineering, Gianluca Molla, University of Insubria, Italy

18:15 – 18:30        Nitric Oxide sensing by the DNR transcription factor from Pseudomonas aeruginosa: a novel heme-dependent mechanism, Nicoletta Castiglione, University of Rome "La Sapienza", Rome, Italy
18:30 - 19:30     POSTER SESSION
FRIDAY - 9 April 2010
09:00 – 11:00     Metallo-proteins (Chairperson: Martino Bolognesi)

09:00 - 09:30        Proteins import and copper transport in mitochondria in a mechanistic systems biology approach, Lucia Banci, CERM & Department of Chemistry, University of Florence, Florence, Italy

09:30 - 10:00        Frataxin: not any longer a function orphan protein, Annalisa Pastore, National Institute for Medical Research, London, UK

10:00- 10:30          Allosteric modulation of heme-albumin reactivity, Paolo Ascenzi, Department of Biology, University of Rome 3, Rome, Italy

10:30 - 10:45        Engineering [FeFe]-hydrogenases for hydrogen bio-gas production by artificial devices, Simone Morra, Univeristy of Turin, Italy

10:45 – 11:00        Biochemical investigations on Zmp1 from Mycobacterium tuberculosis, a Zn-metalloprotease that prevents inflammasome activation and phagosome maturation, Davide Ferraris, Università Piemonte Orientale, Italy

11:00 - 11:20     Coffee break

11:20 – 13:20     Membrane proteins (Chairperson: Ferdinando Palmieri)

11:20 - 11:50        NMR studies reveal the role of biomembranes in modulating ligand binding and release by intracellular bile acid binding proteins, Henriette Molinari, Department of Biotechnology, University of Verona, Verona, Italy

11:50 - 12:20        NMR structure and dynamics of kpOMPA in detergent micelles and in lipid bilayers, Alain Milon, Institute of Pharmacology and Structural Biology, University of Toulouse, Toulouse, France

12:20 - 12:50        Conformational dynamics of a voltage-Gated K+ Channel Chimera Kv1.2/Kv2.1: insights from full atomistic molecular dynamics simulations, Alessando Grottesi, CASPUR, Rome, Italy

12:50 - 13:05        Proteins working, at the membrane-cytosol interface, Enrico Dainese, University of Teramo, Italy

13:05 – 13:20        Is dystroglycan, a membrane receptor involved in muscular dystrophies, a target of the disulphide isomerase ERp57?, Emanuela Angelucci, Università Cattolica, Rome, Italy

13:20 - 14:15     Lunch

14.15 - 15:00      POSTER SESSION

15:00 – 16:50     Proteins, pathological processes and therapeutic strategies (Chairpersons: Bruno Pietro Imbimbo and Massimo Stefani)

15:00 - 15:40        From the dissection of the amyloidogenic pathway to the discovery of intelligent drugs, Vittorio Bellotti, Laboratory of Protein Biochemistry and Pathology of Protein Misfolding Diseases,University of Pavia,  Italy

15:40 - 16:20        Good protein, bad protein: A new amyloid-beta variant can be both, Fabrizio Tagliavini, "Carlo Besta" National Neurological Institute, Milan, Italy

16:20 - 16:35        Protein N-homocysteinylation induces the formation of toxic amyloid-like protofibrils, Paolo Paoli, University of Florence, Italy

16:35 – 16:50        Amyloidogenic potential of transthyretin variants: insights from structural and computational analyses, Antonio Trovato, University of Padua, Italy

16:50 - 17:20     Coffee break

17:20 - 17:50        From target-based to multi-target-based drug design approaches for neglected tropical diseases, Maria Laura Bolognesi, Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy

17:50 - 18.20         NarE: an iron-sulfur cluster-dependent mono ADP-ribosyltransferase from Neisseria meningitidis, Enrico Balducci, Novartis Vaccines & Diagnostics and Department of Comparative Morphology and Biochemistry, University of Camerino, Camerino, Italy

18:20 – 18:35        Molecular defects of the glycine 41 variants of alanine glyoxylate aminotransferase associated with primary hyperoxaluria type I, Barbara Cellini, University of Verona, Italy

18:35 – 18:50     Premio Zanichelli "Prof. Mario Rippa" per il miglior poster - presentazione orale

18:50 - 19:40     POSTER SESSION

20:30 Social Dinner

SATURDAY - 10 April 2010
09:15 – 12:55     Experimental and computational methods to describe protein structure and dynamics (Chairpersons: Menico Rizzi and Andrea Mozzarelli)

09:15 - 10:15      Out of the blue: on flavin-based photoreceptors, Ilme Schlichting, Max Plank Institute for Medical Research, Heidelberg, Germany

10:00 - 10:30      Structural determinants of rhodopsin function and their implications in genetic diseases, Francesca Fanelli, Department of Chemistry, University of Modena e Reggio Emilia, Modena, Italy

10:30 - 10:45      Characterization of the molecular organization and structural stability of an Arginine-binding protein in Thermotoga maritima, Anna Marabotti, CNR Milan-Avellino

10:45 – 11:00     Determination of energy landscapes associated with macromolecular conformational changes from endpoint structures, Massimo Degano, San Raffaele, Milano

11:00 - 11:30     Coffee break

11.30 - 11:45      Structural plasticity and ligand migration in wild type and distal mutants of non-symbiotic hemoglobins from Arabidopsis thaliana, Francesca Spyrakis (Univ. Parma)

11:45 - 12:15       Combining in vitro and in silico studies: the case of Schistosoma mansoni redox proteins, Adriana Miele, Department of Biochemical Sciences, University of Rome "La Sapienza", Rome, Italy

12:15 - 12:55       Computational strategies towards the understanding of ligand migration in proteins, F. Javier Luque, Department of Physico Chemistry, University of Barcelona, Barcelona, Spain
12:55 - 13:10     CONCLUSIONS



Proteine 2010